Cryotherapy is

The term “cryotherapy” literally means “treatment using low temperature” and refers to the removal of skin lesions by freezing them. In the past, carbon dioxide snow was employed, but the most common agent now used by doctors is liquid nitrogen. An aerosol containing a mixture of dimethyl ether and propane is available as Dr. Scholl’s® over-the-counter at pharmacies for use at home.

  • Liquid nitrogen is the liquid state of gaseous nitrogen, which occupies 78% of the air we breathe. Liquid nitrogen is extremely cold, boiling at minus 196°c. It is necessary to store and transport it in special flasks.

Conditions best treated with Cryotherapy

A wide variety of superficial benign lesions can be treated with cryotherapy, but it is most commonly used to remove actinic keratoses (sunlight damage), viral warts, seborrhoeic keratoses and other benign lesions. Occasionally, your dermatologist may suggest using cryotherapy to treat small skin cancers such as basal cell carcinomas and Bowen’s disease.

What is involved in  Cryotherapy

Cryotherapy is done during the course of a routine consultation with your dermatologist, or by your general practitioner or his/her nurse, without any special preparation. Liquid nitrogen is applied to the skin using a spray gun, a metal probe or a cotton bud, and does not normally require a local anesthetic. The procedure lasts just a matter of seconds, the precise time depending on the thickness and size of the lesion. The frozen skin becomes white and takes one to two minutes to thaw to normal skin temperature. Your doctor may suggest that the process is repeated once the skin has thawed out.

Over the succeeding few days, a scab will form, and this will take one to two weeks (and occasionally a little longer, especially on the legs) to come away.
Usually, the treated area will eventually look entirely normal, although scarring and discolouration is possible, particularly on the legs. Depending on the nature of the lesion, more than one treatment may be necessary, and this is usually repeated at one to two monthly intervals.

Your doctor will explain how he/she would like you to care for the treated areas.
  • However, it is usually suggested that they are kept dry until a scab forms, and your doctor may suggest that Vaseline is applied: if wetted they should be patted dry with a soft towel or tissue.
  • It is important not to pick at the scab as this will encourage scarring. A dressing or plaster is not usually necessary, but may be advisable if the treated area is prone to being traumatized or rubbed by clothing.


Side effects of Cryotherapy treatment

Immediate side effects:

  • Pain: cryotherapy can be quite painful, both at the time of treatment and for a variable time thereafter. However, on the whole it is well-tolerated, although sometimes painkillers (such as paracetamol) may be necessary for the first 24 hours. Taking an analgesic an hour or so prior to treatment can reduce the discomfort.
  • Swelling and redness: this is a normal immediate response to freezing the skin, and usually settles after two to three days: your doctor may apply a steroid ointment to the treated area to reduce this. For a short while the treated area may ooze a little. Cryotherapy close to the eyes may induce prominent puffiness of the lower eyelids, which settles within days. 
  • Blistering: this is also a common consequence of cryotherapy and blisters settle after a few days as the scab forms. Some people blister more easily than others, and the development of blisters does not necessarily mean that the skin has been frozen too much. Occasionally, the blisters become filled with blood: this is harmless and only if a blister was very uncomfortable would it be necessary to puncture it, using a sterile needle.
  • Infection: uncommonly, infection can occur, resulting in increased pain and the formation of pus: this may require topical antiseptic or antibiotic therapy.
Subsequent side effects:
  • Scarring: rarely, a scar will form, especially if a deep freeze has been necessary (for instance, to treat a basal cell carcinoma).
  • Pigmentation changes: the skin at and around the treatment site may lighten or darken in colour, especially in dark-skinned people. This usually improves with time, but may be permanent.
  • Numbness: if a superficial nerve is frozen, it may result in numbness of the area of skin supplied by that nerve. Normal feeling usually returns within a matter of months.
  • Treatment may not be effective, or the condition may recur.